From Structure to Behaviour: Why Protein AI Is Entering the Dynamics Era
AlphaFold helped us predict what proteins look like. The next wave of models is starting to address something harder: how proteins move, switch states, and perform functions over time.* By Po-Sung(Sinclair) Huang AlphaFold changed protein science by helping researchers predict what proteins look like with unprecedented scale and accuracy. But proteins do not function as frozen objects. They bend, vibrate, open pockets, switch conformations, and transmit signals across time. That is why the next frontier after structure may be something more difficult and more consequential: behaviour. ...